“The Trusted Choice — Empirically & Prophylactically”.

Ceftriaxone, marketed as Xwega, is a third-generation cephalosporin antibiotic widely used to treat a range of bacterial infections. As a broad-spectrum agent, it is effective against many Gram-positive and Gram-negative bacteria. Included in the World Health Organization’s List of Essential Medicines, it can be administered by intravenous or intramuscular injection.

Indications:

Community- and hospital-acquired pneumonia, complicated UTIs, intra-abdominal infections, skin & soft-tissue infections, bone & joint infections, meningitis, sepsis, gonorrhoea, and surgical prophylaxis.

Pharmaceutical Form:

Sterile powder in vials: 250 mg, 500 mg, 1 g

Reconstitution:

Shake well until fully dissolved.

IM (use 1% Lidocaine – never give IV):

• 250 mg → 2 mL
• 500 mg → 2 mL
• 1 g → 3.5–3.6 mL
IV Injection:


• 250 mg → 3 mL Water for Injection
• 500 mg → 5 mL
• 1 g → 9.6–10 mL

IV Infusion: Further dilute in calcium-free solution (NS or D5W); infuse over 30 minutes.

Dosage:

Adults & children ≥12 years (≥50 kg):

1–2 g once daily (or in divided doses) depending on severity.
Max 4 g/day in severe infections.

Children: 50–80 mg/kg/day (max 2–4 g).
Uncomplicated gonorrhoea: 250–500 mg single IM dose.